Dual TCR T Cells: Identity Crisis or Multitaskers?

Using Dual-TCR-Expressing T Cells Study of the Mechanism of TCR Antagonism

Seamounts: identity crisis or split personality?

Less than 100 years after Mosely’s statement, Hubbs (1959) contemplated the ‘scientific interests, particularly in respect to zoogeography and speciation’ of recently discovered submerged mountains in the Pacific Ocean. Approximately 14,000 seamounts, undersea mountains peaking below sea level (Wessel, 2001; Kitchingman & Lai, 2004), rise up from the ocean bottom. Like terrestrial mountains (Br...

TCR T cells in vivo

Whereas most peripheral CD8 T cells highly express CD8 heterodimer in healthy individuals, there is an increase of CD8 low or CD8 T cells in HIV infection or Wiskott-Aldrich syndrome and after bone marrow transplantation. The significance of these uncommon cell populations is not well understood. There has been some question as to whether these subsets and CD8 high cells belong to different ont...

Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells.

Redirecting Ag specificity by transfer of TCR genes into PBLs is an attractive method to generate large numbers of cytotoxic T cells for immunotherapy of cancer and viral diseases. However, transferred TCR chains can pair with endogenous TCR chains, resulting in the formation of mispaired TCR dimers and decreased or unspecific reactivity. TCR gene transfer into hematopoietic stem cells (HSCs) i...

Identity crisis?

This article responds to arguments made in a recent paper by Bucholtz and Hall (Bucholtz, M., Hall, K., 2004. Theorizing identity in language and sexuality research. Language in Society 33, 469–515), in which two contrasting approaches to language and sexuality, dubbed ‘‘identity-based’’ and ‘‘desire-centered’’, are identified, and the latter is critiqued. As well as seeking to correct some ina...